Immunhistochemical analysis of Nuclear Factor Kappa Beta expression in etiopathogenesis of ovarian tumors

Abstract Purpose: To investigate the place of the transcription factor nuclear kappa B (NF-kB), which is a marker of chronic inflammation, in the etiology of the ovarian carcinoma. Methods: NFkB analysis with the immunohistochemical method has been performed. To evaluate immunohistochemical NF-kB expression in the ovarian tissue, the H-score method. H-score = ∑ Pi (i+1), where ''Pi'' is the percentage of stained cells in each intensity category (0-100%) and ''i'' is the intensity indicating weak (i=1), moderate (i=2) or strong staining (i=3). Results: It has been seen that, the mean H score is statistically significantly higher in the patient group with serous and musinous adenocarcinoma diagnosis than the two other patient groups (p<0.005). Conclusions: Factor nuclear kappa B is an important mediator that acts in the chronic inflammation. The highest expression rates are determined by the immunohistochemical method in the ovarian cancer group.

Cistoadenoma Seroso Microquistico Multifocal de páncreas: reporte de un caso / Multifocal microcystic serous cystadenoma of the pancreas: case report

Presentamos el caso de una paciente cuyo diagnóstico anatomo-patológico fue Cistoadenoma seroso micro-quístico multifocal de páncreas, realizamos una revisión de las alternativas diagnósticas y las diferentes propuestas terapéuticas de este infrecuente tumor pancreático.

A cystic hepatic lesion: when to worry? / La lesión cística del hígado: ¿cuándo preocuparse?

A 16-year old female presented to hospital with abdominal pain. Features on computed tomography raised the possibility of biliary cystadenoma or cystadenocarcinoma. She underwent a liver resection, and histopathology confirmed a serous biliary cystadenoma. This case is presented to highlight the radiological features of this uncommon pre-malignant condition as well as to summarize a management algorithm for cystic liver lesions.

Una mujer de 16 años de edad acudió al hospital con un dolor abdominal. Las características observadas con tomografía computarizada apuntaban a un cistoadenoma biliar o un cistoadenocarcinoma como diagnósticos diferenciales. La paciente fue sometida a una resección del hígado, y la histopatología confirmó un cistoadenoma biliar seroso. Presentamos este caso para resaltar los rasgos radiológicos de esta condición premaligna rara, así como para resumir un algoritmo de tratamiento para las lesiones císticas de hígado.

Cistoadenoma seroso gigante hallazgo intraoperatorio: a propósito de un caso / Giant serous cyst adenoma intraoperating finding: a purpose of a case

Se presenta caso de paciente 32 años de edad III G, II C con embarazo de 38 SEM x FUR quién ingresa por presentar CsUsDs, se realiza cesárea segmentaría evidenciando durante el acto operatorio tumoración de ovario gigante ubicada en ovario izquierdo se realiza exeresis y el estudio anatomopatológico confirma que se trata de cistoadenoma seroso.

Cistoadenoma seroso benigno y embarazo: a propósito de un caso en el Hospital Dr. Patrocinio Peñuela Ruíz / Benign serous cystoadenoma and pregnancy: a purpose of a case in the Hospital Dr. Patrocinio Peñuela Ruíz

El cistoadenoma seroso, es un tipo tumor derivado del epitelio superficial celómico, de los cuales 70 por ciento son benignos; siendo la incidencia de masas anexiales en el embarazo aproximadamente de 1 de cada 600 embarazos, correspondiendo a malignas hasta un 5 por ciento. Se describe el caso de paciente de 28 años de edad, II gesta, I para; quién cursa con embarazo de 11 semanas + 1 día por FUM, la cual cursa con dolor en hipogastrio y fosa ilíaca derecha de 5 semanas de evolución, con ecografía que reporta tumoración de ovario derecho, con aumento progresivo de la intensidad del dolor y crecimiento rápido del tamaño de la tumoración.

Twisted mixed germ cell tumor of the ovary in a child

We report an 8-year-old female patient with a mixed germ cell stromal tumor MGCT of the left ovary. Exploration revealed that the tumor had been twisted around its pedicle. These ovarian tumors are classified among interesting type of tumors due to the variability of neoplastic tissues in the same tumor mass, in the twisted ovarian tumor. Four histological types of tumor tissues were found: well-differentiated adenocarcinoma, dysgerminoma, immature teratoma, and focus of papillary serous cyst adenoma as well. During our review of the literature, this reported case of MGCT of the ovary was among the extremely rare cases, which had been reported. Mixed germ cell tumor is well documented in the literature since 1950

Ovarian tumours: a study of 282 cases.

Histologically 282 ovarian tumours were studied, of these 212 (75.2%) were benign, 8 (2.8%) of borderline malignancy and 62 (21.9%) were malignant. The tumours were classified according to WHO classification. Epithelial tumours were the commonest variety constituting 70.9% of all the ovarian tumours followed by germ cell tumours (21.2%), sex cord stromal tumours (6.7%) and metastatic tumours (0.7%). Among the individual tumours, serous tumours (42.9%) were the commonest, followed by mucinous tumours (25.5%), teratomas (17%), granulosa cell tumours (6.7%), dysgerminomas (2.48%) and endodermal sinus tumours (1.77%). Two cases (0.7%) of endometrioid carcinomas and one case (0.35%) of clear cell carcinoma were encountered. Ovarian tumours were found to occur in the age range of 8 months to 74 years. Peak incidence was between 21 and 40 years age group.

Tumor papilar peritoneal seroso de bajo potencial maligno: comunicación de un caso / Primary peritoneal serous tumor with potentially low malignancy: report of 1 case

Papillary serous carcinoma with low malignant potential, similar to those described in the ovary, can also originate in the peritoneum. Characteristically they show peritoneal spread without involvement of the ovary and, if present, it corresponds to a superficial implant similar to those seen in the rest of the peritoneal cavity. Histologically they correspond to a low malignant potential tumor; they are slow growing and have good prognosis. They are common in young women, usually they present few symptoms and are frequently discovered during other surgical procedures. The treatment is surgical and it can be conservative in cases of women who want to preserve their fertility, without coadyuvant therapy. We report a 34 years old woman with a primary peritoneal serous carcinoma with low malignant potential and discuss its management

Cystic struma ovarii: a rare presentation of an infrequent tumor

CONTEXT: Struma ovarii, a rare neoplasm, is a monophyletic teratoma composed of thyroid tissue. It is generally considered to account for less than 5 percent of mature teratomas. CASE REPORT: A diagnosis of struma ovarii may be the source of many diagnostic problems. It may be cystic and microscopic examination may only reveal a few typical thyroid follicles, resulting in confusion with other cystic ovarian tumors. Extensive sampling should be undertaken and immunohistochemistry may be decisive in establishing the thyroid nature of the epithelial lining. The authors report two cases of cystic struma ovarii, and discuss diagnostic criteria and the limitations of frozen biopsies in these tumors

Cistadenoma seroso de páncreas. A propósito de 5 pacientes / Serous cystadenoma of the pancreas. A propos of 5 patients

Objetivo. Describir el curso clínico, tratamiento quirúrgico y evolución postoperatoria de un grupo de pacientes con cistadenoma seroso de páncreas. Diseño. Descripción de casos clínicos. Estudio retrospectivo. Sede Hospital de tercer nivel de atención. Pacientes y métodos. Se revisaron los expedientes clínicos de 5 pacientes que presentaron cistoadenoma seroso de páncreas; se analizaron los siguientes datos: edad, sexo, cuadro clínico, métodos de diagnóstico empleados, tratamiento quirúrgico utilizado, resultado histopatológico, morbilidad y mortalidad. Resultados. Cuatro de los 5 pacientes fueron mayores de 50 años; la sintomatología predominante fue dolor abdominal y masa palpable. El estudio diagnóstico más confiable fue la tomografía computada (TAC). En un paciente el cistoadenoma fue hallazgo de autopsia, en los 4 restantes fue posible la resección de la masa. En todos los casos se confirmó histopatológicamente la presencia de un cistoadenoma seroso. La evolución postopertoria fue satisfactoria en todos los casos

Pancreatic serous cystadenoma mimicking pseudocyst

The serous cystadenoma of the pancreas is a rare lesion that is usually found incidentally. It is mostly observed as a spongy microcystic mass but rare variants such as macrocystic, unicystic, or multicentric are also seen. We recently experienced a unique case of unicystic serous cystadenoma mimicking a pseudocyst. It was grossly a unilocular cyst with surrounding dense fibrosis resembling a pseudocyst. Microscopically, the cyst was partly lined by low columnar-to-cuboidal cells with clear cytoplasm containing glycogen.

Surface epithelial tumours of the ovary.

Surface epithelial tumours (SET) constituted 65.7% of all the ovarian tumours. Benign tumours were 182 (71.9%), of low malignant potential (LMP) 11 (4.4%) and frank malignant 60 (23.7%). Maximum number of cases, 102 (40.3%) belonged to 3rd decade. Mean age for serous cystoma was 31.5% years as compared to 30.8 years for mucinous cystoma. The commonest presenting feature was the abdominal lump observed in 182 cases (71.9%) and pain in abdomen in 120 (47.4%).Serous cystomas were t he most frequent tumours and comprised of 32.21% of all the ovarian tumours or 46.01% of all the SET or 65.56% of all the cystic SET. Seventeen (11.7%) of serous tumours were bilateral. Mucinous cystomas constituted 14.55% of all the ovarian tumours or 30.8% of all the SET. These tumours were bulky (78.6%; 15 cm diameter) and multilocular (83.9%).Mucinous cystadenocarcinoma was the commonest malignant epithelial tum our (36.6%). Endometroid carcinoma comprised 3.65% of all the SET or 8.4% of all the ovarian malignancy. Squamous metaplasia was seen in one case whereas 2 cases were of mesodermal mixed tumour with heterologous element as rhabdomyosarcoma. Clear cell carcinoma, Brenner tumour and unclassified group constituted 0.79%, 1.18% and 1.58% of all SET respectively.